Article by Ceri Wheeldon
The third article in our series on longevity, and changes we can make to live longer and healthier lives.
According to scientists , a 120 year life span is feasible for people being born today. But if we live longer, what can we do to ensure our later years are healthy and productive? This is the second in a three part series where I asked Yuri Medzinovsky, Director General of Longevity & Beauty Residence GLMED, and some of his medical colleagues about the prospects for extending lifespan to 120 years (and staying active and healthy as well) There is a lot of information which is why I have split the answers into three separate posts to make it a little easier to digest.
Q: How does biological age differ from chronological age? What are longevity markers?
An: Age, when measured chronologically, may not be a reliable indicator of the body’s rate of decline or physiological breakdown, but rather, serves only as a proxy for the rate of ageing. Nevertheless, in order to better assess an individual’s degree of ageing, and thus residual life span or susceptibility to disease, new approaches need to be developed that provide predictive power beyond what is gained from measuring chronological age alone. To better evaluate the ageing process and predict the occurrence of ageing related diseases, the conception of biological age was proposed to describe the changes of body function with the same or similar chronological age in an objective way. The biological ageing is defined as a process or a group of processes that result in the progressive decrement of viability of the organism with advancing age.
The successful development and implementation of interventions to promote healthspan will require the use of longevity markers (ageing markers). These biomarkers are defined as biological characteristics that can be objectively measured and evaluated as indicators of age-related normal and pathological processes. In practice, such biomarkers should aid in diagnosing individual ageing phenotypes, predicting the progression of these phenotypes, selecting possible interventions, and evaluating the effects and outcomes of such interventions.
In the GLMED Longevity & Beauty Residence, Moscow we use the following panel:
Q: What can we do to reduce our biological age?
An: Given all of the above, a comprehensive approach should be applied. According to the experience of the GLMED Longevity & Beauty Residence, we can recommend a programme like the one we offer at our clinic. We would start with a multi-level check up looking at your current biological age and longevity markers. We would then define your top priority goals forming a personalised programme for comprehensive rejuvenation. We would implement an annual programe, with ongoing follow up, adjusting as required to improve your quality of health and deceleration of the external signs of ageing.
The purpose is to create an effective individual programme to prevent the development and progression of chronic diseases and age related conditions. The programme would include:
- Treatment of revealed acute and chronic diseases (cardiovascular, gastrointestinal, respiratory etc.
- Impact on the factors of premature ageing and age-related conditions:
- individual physical activity programme (according to genetic analysis and functional parameters
- individual diet for healthy ageing (according to genetic analysis and laboratory tests)
- overcoming bad habits (smoking, excess alcohol)
- Stress management (psycotherapy, acupuncture etc)
- neutralization of inflammaging, oxidative stress, asymptomatic hormonal deviations
Regular detoxification plays an important role in reducing biological age.
Q. How long would it take to see any impact on biological age on changes we may make re lifestyle, diet etc?
An: According to our experience, if someone fully immerses themselves in the programme (i.e are willing to change their lifestyle and adhere to medical advice), it takes a minimum of 6 to 12 months to see any impact on their biological age. The optimal goal of any anti-ageing intervention is to decrease one’s biological age by 10 years which corresponds to the mechanisms of HEALTHY AGING.
Q. How significant would impact of lifestyle changes be on biological age without the peptide therapy?
An: According to scientific data, when it comes to the reduction of the development of age-related diseases and consequently, biological age, correction diet and lifestyle plays a significant role in anti-aging medicine. Thus, individualized lifestyle changes together with optimal sleep patterns, the right levels of physical activity and improved stress tolerance could extend life by up to 50 % (this is supported by information about the population of long-livers in Sardinia and Japan). That is precisely why in Longevity and Beauty Residence GLMED (Moscow), the methods of active longevity are primarily deployed at the stage where lifestyle and diet are comprehensively analyzed and corrected. However, in order for lifestyle recommendations to be most effective, one cannot simply rely on general recommendations; routines must be personalised. When it comes to diet, it is necessary to perform genetic studies to identify the specifics of the intestinal absorption of vitamins, the food group which digestion takes less body energy, and the body’s gluten tolerance All of these individual factors determine our longevity.
Another scientifically based method of achieving active longevity involves calorie restriction while maintaining a careful balance between macronutrients and fibre that removes toxins from one’s intestines, thus providing protection against inflammatory processes and cancer. Food content also plays an important role here, as certain diets delay ageing and others speed it up by affecting the signaling pathways of longevity genes. Components of Mediterranean, Nordic and Okinawa diets, as well as the exclusion of red meat, support life extension and health promotion.
Part One: Impact of lifestyle on age
Part 2: Role of telomeres and peptides on age